Cantho City is located in the center of the Mekong Delta. It is contiguous to 5 provinces: An Giang on the north, Dong Thap on the north-east, Hau Giang on the south, Kien Giang on the west, and Vinh Long on the east. Cantho has a complex of rivers and canals such as Hau, and Can Tho rivers, Thot Not, O Mon canals. Among them, the Hau Riveris considered a benefactor of this region, since yearly floods deposit large quantities of alluvia to the rice fields. Thank to that Cantho becomes "the green lungs of the Mekong Delta".The climate is harmonized with few of storms. It is hot, humid all year. Rainy season lasts from May to November, and dry season lasts from December to April. The annual average temperature is 27ºC.

The floating markets are very lively scenery, accommodating much of the goods exchange on the area, and can be quite freely visited on board smaller boats.